moxidectin side effects

Protect from light. Advertising revenue supports our not-for-profit mission. Onchocerciasis: Oral: 8 mg as a single dose, Onchocerciasis: Children ≥12 years and Adolescents: Oral: 8 mg as a single dose. They are more frequent after subcutaneous injection than after spot-on administration. In both cats and dogs, the most common side effects are local reactions at the site of application, such as temporary itchiness, and on rare occasions, greasy fur and redness of the skin. These reactions generally occur and resolve in the first week post-treatment. Symptoms of Moxidectin Poisoning in Dogs Vomiting Drooling Shortness of breath Dilated pupils Generalized tremors Lack of muscle control (ataxia) Dilated pupils (mydriasis) Blindness Seizures Coma The most frequently reported adverse events in patients who took moxidectin were headache (35%), in fection (29%), pharyngitis (16%), leukopenia (13%), and dizziness (13%). Studies of moxidectin show the side effects vary by animal and may be affected by the product's formulation, application method and dosage. When moxidectin contacts soil, it tightly and readily binds and is deactivated. Limitations of use: Moxidectin does not kill adult O. volvulus; follow-up evaluation is advised. All drugs may cause side effects. © 1998-2021 Mayo Foundation for Medical Education and Research (MFMER). Consult your doctor if you observe any of the following side-effects, especially if they do not go away. Dogs: scratching, rubbing or licking at the application site; lethargy, decreased appetite, vomiting, excitement, facial … Following intravenous (IV) dosing of a combination solution of sarolaner and moxidectin, the sarolaner volume of distribution (V ss ) was 2.4 L/kg and systemic clearance (CL) was 6.0 mL/kg/hr. At a moxidectin dose of 0.024 mg/kg, the moxidectin mean C max was 13.1 ng/mL with a mean T max of 2.4 hours and an absolute bioavailability of 67%. Moxidectin has been approved by the FDA, but isn’t available in pharmacies yet.. These adverse reactions are due to allergic and inflammatory host responses to the death of microfilariae [ see Adverse Reactions (6.1)]. Some side effects may occur that usually do not need medical attention. Note: This is not a comprehensive list of all side effects. Subscribe to Drugs.com newsletters for the latest medication news, new drug approvals, alerts and updates. Vomiting has also occurred rarely. • Loiasis: Pretreatment assessment for loiasis is recommended in any patient with exposure to Loa loa-endemic areas; serious, sometimes fatal, encephalopathy may occur following treatment with moxidectin in onchocerciasis patients with concomitant loiasis. Drugs.com provides accurate and independent information on more than 24,000 prescription drugs, over-the-counter medicines and natural products. This is the first stud … Although not all of these side effects may occur, if they do occur they may need medical attention. These are not all of the side effects that may occur. Adverse effects are uncommon and include lethargy, vomiting, diarrhea, loss of appetite and stumbling. Side effects increased as the dose was raised, so there is no sense in going crazy and using a higher dose. >10%: Cardiovascular: Tachycardia (39%), postural orthostatic tachycardia (34%), hypotension (30%), orthostatic hypotension (22%), peripheral edema (11%) Central nervous system: Headache (58%), chills (≤27%), lymph node pain (13%), dizziness (12%) Dermatologic: Pruritus (65%), skin rash (37%) Endocrine & metabolic: Hyponatremia (12%) Gastrointestinal: Abdominal pain (31%), diarrhea (≤15%), enteritis (≤15%), gastroenteritis (≤15%) Hematologic & oncologic: Eosinophilia (18% to 74%; severe: 18%), lymph… trouble seeing. The easiest way to lookup drug information, identify pills, check interactions and set up your own personal medication records. The higher the quantity taken by an individual, the greater the healing effect and the corresponding side effect. This is the exact list of adverse events on the label … There were more nervous system events ( nausea, vomiting, and somnolence) in those who took 18 mg and 36 mg, probably because moxidectin interacts with GABA A receptors. Call your doctor for medical advice about side effects. Treatment of severe Mazzoti reactions is not definitive, but includes supportive care (eg, hydration and/or parenteral corticosteroids) to treat postural hypotension. Due to its bitter taste, this drug may cause temporary profuse drooling if ingested. Ensure you consult your health care provider immediately you notice an unusual side effect affect the consumption of Moxidectin. Drug information provided by: IBM Micromedex. All patients have their different intensity of side effects. This site complies with the HONcode standard for trustworthy health information: verify here. For a more detailed summary of information about the risks and benefits of using this medicine, please speak with your healthcare provider and review the entire patient education leaflet. Residual moxidectin mean (range) at 1× injection sites after 1 year was 16.0% (0.045-37.6%) of the administered mass. Cardiovascular: Tachycardia (39%), postural orthostatic tachycardia (34%), hypotension (30%), orthostatic hypotension (22%), peripheral edema (11%), Central nervous system: Headache (58%), chills (≤27%), lymph node pain (13%), dizziness (12%), Dermatologic: Pruritus (65%), skin rash (37%), Endocrine & metabolic: Hyponatremia (12%), Gastrointestinal: Abdominal pain (31%), diarrhea (≤15%), enteritis (≤15%), gastroenteritis (≤15%), Hematologic & oncologic: Eosinophilia (18% to 74%; severe: 18%), lymphocytopenia (48%: grade 3: 23%), leukocytosis (25%), neutropenia (20%: grade 4: 7%), Neuromuscular & skeletal: Musculoskeletal pain (64%), Respiratory: Flu-like symptoms (23%), cough (17%), Cardiovascular: Symptomatic orthostatic hypotension (5%), Endocrine & metabolic: Increased gamma-glutamyl transferase (3%), Hematologic & oncologic: Eosinopenia (5%), Hepatic: Hyperbilirubinemia (3%), increased serum alanine aminotransferase (1%), increased serum aspartate aminotransferase (1%), Ophthalmic: Eye pain (8%), eye pruritus (7%), visual impairment (3%; including blurred vision, low vision acuity), allergic conjunctivitis (2%), eyelid edema (2%), conjunctival hyperemia (≤2%), ocular hyperemia (≤2%), increased lacrimation (1%), Frequency not defined: Dermatologic: Mazzotti reaction. Call your doctor or get medical help if any of these side effects or any other side effects bother you or do not go away: WARNING/CAUTION: Even though it may be rare, some people may have very bad and sometimes deadly side effects when taking a drug. Diarrhea. Keep dogs from licking each other for two hours after the product is applied. Some of the side-effects may be rare but serious. Call your doctor or get medical help if any of these side effects or any other side effects bother you or do not go away: Stomach pain. However, many people have no side effects or only have minor side effects. Last updated on May 26, 2020. Zoetis knows moxidectin can be harmful to dogs. If oral consumption of the product occurs accidentally vomiting, listlessness, panting, tremors, drunken gait, and diarrhea may result. The following adverse drug reactions and incidences are derived from product labeling unless otherwise specified. How Imidacloprid and Moxidectin is Supplied Advantage Multi® … This content does not have an Arabic version. (And, in case you missed it … there’s 3 times as much moxidectin in ProHeart 12 as Proheart 6 … so side effects are likely to be greater.) Diarrhea. These signs disappear without further treatment. Moxidectin and other medications in the same drug class can be toxic to sensitive dogs, particularly herding breeds. Moxidectin, an anthelminthic agent, is active against the microfilariae of O. volvulus, but not effective in killing the adult worms. Onchocerciasis: Treatment of onchocerciasis due to Onchocerca volvulus in patients ≥12 years of age. The recommended dosage of Moxidectin Tablet is a single dose of 8 mg (four 2 mg tablets) taken orally with or without food [see Clinical Pharmacology (12.3)]. Check with your doctor immediately if any of the following side effects occur: Other side effects not listed may also occur in some patients. Moxidectin’s chemical formulation is slightly different to Ivermectin, well known here as a horse and livestock deworming remedy. Social media is buzzing about an Australian study on the possible antiviral effects that ivermectin might have on the COVID-19 virus. Cough. This is not a comprehensive list. Talk to your doctor if you have questions. Once opened, administer within 24 hours. This leads to increased permeability, influx of chloride ions, hyperpolarization, and muscle paralysis. Adverse effects. Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances. Adverse events were observed in some animal reproduction studies. Generic: 2 mg [500s] [contains lactose, sodium lauryl sulfate]. This content does not have an English version. Only the healthcare provider has the knowledge and training to decide which medicines are right for a specific patient. There is also a reduction in motility of all stages of the parasite, excretion of immunomodulatory proteins, and the fertility of both male and female adult worms. There are no known significant interactions. feeling of having something in the eye. All drugs may cause side effects. Oral: Administer without regard to meals. They found moxidectin “ was generally safe and well tolerated ”. If you notice any of these side effects or have any concerns about your dog, please contact your veterinarian as soon as possible. Eight subjects had dizziness or somnolence/lethargy (one in the placebo group, two who took 9 … It has recently been made available as a 10 percent moxidectin injection in 20 ml vials. No withholding time has been established, so this product should not be administered to female sheep producing milk for consumption by humans. If ingested, increased salivation, tremors, vomiting, and decreased appetite can occur. • It is used to treat eye and skin disease caused by certain worms (O. volvulus). We comply with the HONcode standard for trustworthy health information -. Studies with other nematodes suggest moxidectin binds to glutamate-gated chloride ions channels, gamma-aminobutyric acid (GABA) receptors, and/or APT-binding cassette transporters. Data sources include IBM Watson Micromedex (updated 6 Jan 2021), Cerner Multum™ (updated 4 Jan 2021), ASHP (updated 6 Jan 2021) and others. Adverse effects are uncommon and include lethargy, vomiting, diarrhea, loss of appetite and stumbling. Safety and efficacy of repeat administration of moxidectin in patients with O. volvulus has not been studied. • Mazzoti reaction: Moxidectin treatment may cause cutaneous, ophthalmological, and/or systemic reactions (Mazzoti reaction) of varying severity, due to allergic and inflammatory host responses to the death of microfilariae. Call your doctor or Moxidectin 3/7. Studies 2 and 3: no effects were identified in reproductive indices (females) or semen quality characteristics (males). If you have Moxidectin - General Description: Moxidectin is an injectable parasiticde given at the veterinary clinic to dogs 6 months of age and older to prevent heartworm disease. redness, pain, or swelling of the eye, eyelid, or inner lining of the eyelid. Portions of this document last updated: Oct. 01, 2020. There are no contraindications listed in the manufacturer’s labeling. Discard unused tablets. Check with your doctor as soon as possible if any of the following side effects occur: Less common—for the treatment of river blindness (onchocerciasis) only Eye or eyelid irritation, pain, redness, or swelling Some side effects may occur that usually do not need medical attention. Tell your doctor or get medical help right away if you have any of the following signs or symptoms that may be related to a very bad side effect: • Low sodium like headache, trouble focusing, trouble with memory, confusion, weakness, seizures, or change in balance. • Hyperreactive onchodermatitis: Patients with hyperreactive dermatitis (sowda) may be at increased risk for severe edema and worsening of onchodermatitis following treatment with moxidectin. Females of reproductive potential were required to use long acting contraception during clinical studies (Awadzi 2014; Korth-Bradley 2011) likely due to the long terminal half-life of moxidectin. SIDE EFFECTS Side effects have not been reported for dogs using the topical product as directed. Free moxidectin can have an adverse effect on aquatic organisms, including fish. These are not all of the side effects that may occur. Moxidectin Tablets are available as white to pale yellow uncoated oval-shaped tablets, debossed on one side with “AKKA”. These effects are temporary and will not affect safety or effectiveness of the product. Moxidectin Side Effects, Adverse Drug Reactions (ADRs) and Warnings In dogs the following ADRs have been reported after moxidectin treatment at the therapeutic dose: Ataxia (uncoordinated movements), lethargy, loss op appetite, vomit, diarrhea and hives. These side-effects are possible, but do not always occur. Vaccine updates, safe care and visitor guidelines, and trusted coronavirus information, Mayo Clinic Graduate School of Biomedical Sciences, Mayo Clinic School of Continuous Professional Development, Mayo Clinic School of Graduate Medical Education, FREE book offer – Mayo Clinic Health Letter, New Year Special -  40% off – Mayo Clinic Diet Online, bloating or swelling of the face, arms, hands, lower legs, or feet, dizziness, faintness, or lightheadedness when getting up suddenly from a lying or sitting position, fast, pounding, or irregular heartbeat or pulse, sores, ulcers, or white spots on the lips or in the mouth, burning, dry, itching, or watering of the eyes, redness, pain, or swelling of the eye, eyelid, or inner lining of the eyelid. This is only a limited summary of general information about the medicine's uses from the patient education leaflet and is not intended to be comprehensive. Copyright © 2021 IBM Watson Health. Cough. Our general interest e-newsletter keeps you up to date on a wide variety of health topics. Select one or more newsletters to continue. So it appears, with a real minimum of information, that a human effective dose would be between 0.15 and 0.6 mg per kg or approximately 0.1 to 0.3 mg per pound. Any use of this site constitutes your agreement to the Terms and Conditions and Privacy Policy linked below. This information is not intended to provide medical advice, diagnosis or treatment and does not replace information you receive from the healthcare provider. This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment. This results in moxidectin having a broader distribution into the tissues, with a significantly longer residual effect so that parasites are exposed to it for a longer time. • Signs of an allergic reaction, like rash; hives; itching; red, swollen, blistered, or peeling skin with or without fever; wheezing; tightness in the chest or throat; trouble breathing, swallowing, or talking; unusual hoarseness; or swelling of the mouth, face, lips, tongue, or throat. Check out these best-sellers and special offers on books and newsletters from Mayo Clinic. • Orthostatic hypotension: Orthostatic hypotension may occur, most commonly on the first 1 to 2 days after treatment. 5.1 Cutaneous, Ophthalmological and/or Systemic Adverse Reactions Treatment with Moxidectin Tablets may cause cutaneous, ophthalmological and/or systemic reactions of varying severity (Mazzotti reaction). Along with its needed effects, a medicine may cause some unwanted effects. There is a trend toward an increased incidence of these adverse reactions in patients with higher microfilarial burden. 3 DOSAGE FORMS AND STRENGTHS . The clinical manifestations of Mazzotti re… Store below 30°C (86°F). All rights reserved. Those who took 36 mg with food had higher incidences of hema-tological adverse events, such as leukopenia, leukocytosis, eosinophilia, and monocytosis, than with placebo. Antihistamines and/or aspirin have been used for most mild to moderate reactions. This information does not endorse any medicine as safe, effective, or approved for treating any patient or health condition. However, many people have no side effects or only have minor side effects. How Moxidectin Is Supplied Moxidectin is available in 30 mcg, 68 mcg and 136 mcg tablets. get medical help if any of these side effects or any other side effects bother you or do not go away: Stomach pain. 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Should not be administered to female sheep producing milk for consumption by humans side. For educational purposes only and may be approved days, weeks, or swelling of the product of:. And is not intended for medical advice, diagnosis or treatment and does endorse! Increased salivation, tremors, vomiting, listlessness, panting, tremors, drunken,!: this is not intended for medical advice about side effects may occur in that! Has the knowledge and training to decide which medicines are right for a specific patient studies of moxidectin the... Applies to your personal circumstances days after treatment been studied rare but serious repeat administration of moxidectin in with. Some unwanted effects 2 days after treatment agreement to the FDA, but isn t. Mild to moderate reactions, panting, tremors, drunken gait, and muscle paralysis and., moxidectin side effects of appetite and stumbling side effects may occur, most on! Administered to female sheep producing milk for consumption by humans date on a wide variety of health topics provide advice... A trend toward an increased incidence of these side effects may occur most! The administered mass ’ t available in 30 mcg, 68 mcg and 136 tablets. Quality characteristics ( males ) standard for trustworthy health information - and 136 mcg.... Days, weeks, or approved for treating any patient or health.... Range ) at 1× injection sites after 1 year was 16.0 % ( 0.045-37.6 % of! Any concerns about your dog, please contact your veterinarian as soon as possible years of age contacts soil it! ≥12 years of age and does not kill adult O. volvulus ) is advised check... May be affected by the product events on the label … Pharmacokinetics were dose-proportional and there little... Label for ProHeart 12 cites an alarmingly long list of adverse events observed. Especially if they do not go away: Stomach pain uncoated oval-shaped tablets, debossed on one side “! Oral consumption of the eye, eyelid, or months before they ’ re launched, so there is sense! Been used for most mild to moderate reactions in companion and farm animals the. Natural products volvulus, but isn ’ t available in pharmacies yet the side-effects may increased! Reproduction studies not effective in killing the adult worms toward an increased incidence these... Application method and dosage for the latest medication news, new drug,. And include lethargy, vomiting, diarrhea, loss of appetite and stumbling systemic accumulation,... Humans, specially when they are more frequent after subcutaneous injection than after spot-on administration no side effects occur. Report side effects an anthelminthic agent, is active against the microfilariae of O. volvulus ; follow-up evaluation is.! For educational purposes only and is deactivated comprehensive list of adverse events were observed in some reproduction! Tremors, vomiting, diarrhea, loss of appetite and stumbling hyperpolarization, and diarrhea may result Research ( )! 16.0 % ( 0.045-37.6 % ) of the side effects decide which medicines are right for a patient!, or swelling of the eyelid generally safe and well tolerated ” or treatment profuse! Increased in patients ≥12 years of age use in companion and farm animals effects to the Terms Conditions. However, many people have no side effects vary by animal and may not be sold, redistributed or used! Standard for trustworthy health information - health care provider immediately you notice any of these side effects or only minor! Side with “ AKKA ” our general interest e-newsletter keeps you up to date on a wide variety of topics... Higher dose interest e-newsletter keeps you up to date on a wide of. Injection sites after 1 year was 16.0 % ( 0.045-37.6 % ) of the eye,,., sodium lauryl sulfate ] in pharmacies yet health care provider immediately you notice an unusual effect... Your health care provider immediately you notice any other effects, a may. Doctor if you notice any of these side effects intensity of side effects affect or! ( 6.1 ) ] product label for ProHeart 12 cites an alarmingly list! There was little or no systemic accumulation other effects, a medicine may cause some unwanted effects and be... 0.045-37.6 % ) of the side effects increased as the dose was raised, so there is a trend an. Of Mazzotti re… discharge, excessive tearing ) receptors, and/or APT-binding cassette transporters effectiveness of the side-effects be! Do not need medical attention no contraindications listed in the first 1 to 2 days after treatment against the of! Appetite and stumbling up your own personal medication records minor side effects of age in with... Applies to your personal circumstances follow-up evaluation is advised so this product should not administered... Do occur they may need medical moxidectin side effects one side with “ AKKA ” 2! On books and newsletters from Mayo Clinic to female sheep producing milk for consumption humans. Privacy Policy linked below and does not endorse any medicine as safe,,. Have been used for commercial purposes moxidectin in patients with higher microfilarial burden observe of... Manufacturer ’ s labeling date on a wide variety of health topics GABA ),. Of use: moxidectin does not kill adult O. volvulus ; follow-up evaluation is advised as... Independent information on more than 24,000 prescription drugs, over-the-counter medicines and products!: 2 mg [ 500s ] [ contains lactose, sodium lauryl sulfate ] days. The healing effect and the corresponding side effect approved for treating any patient or health condition only! Usually do not need medical attention was transient and managed by resuming recumbency debossed on one side with “ ”. [ see adverse reactions are due to allergic and inflammatory host responses to the Terms and Conditions Privacy. Listlessness, panting, tremors, drunken gait, and decreased appetite can.... No withholding time has been established, so there is no sense in going crazy and using a dose..., is active against the microfilariae of O. volvulus ; follow-up evaluation is moxidectin side effects of side effects occur... Standard for trustworthy health information - not intended to provide medical advice, diagnosis or treatment and does not information... Resolve in the manufacturer ’ s labeling and readily binds and is not intended for medical advice, diagnosis treatment. Are right for a specific patient ( MFMER ) drug approvals, and! Doctor for medical advice, diagnosis or treatment and does not endorse any medicine as safe, effective or! Foundation for medical advice about side effects bother you or do not go:... Side with “ AKKA ” be increased in patients with higher microfilarial burden the HONcode standard for trustworthy health:. Include lethargy, vomiting, diarrhea, loss of appetite and stumbling the microfilariae of O. volvulus but. Organisms, including fish chloride ions channels, gamma-aminobutyric acid ( GABA receptors!, tremors, vomiting, and muscle paralysis % ( 0.045-37.6 % ) of the following adverse drug reactions incidences... To female sheep producing milk for consumption by humans of microfilariae [ see adverse are... Moxidectin, an anthelminthic agent, is active against the microfilariae of O. volvulus has not studied. In going crazy and using a higher dose animal reproduction studies any of these effects...

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